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AttributesValues
rdf:type
rdfs:label
  • Lonafarnib
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Lonafarnib
NSC_Code
  • 719467
UMLS_CUI
  • C1257385
CAS_Registry
  • 193275-84-2
FDA_UNII_Code
  • IOW153004F
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anticancer drug that belongs to the family of drugs called enzyme inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43503
PDQ_Closed_Trial_Search_ID
  • 43503
Chemical_Formula
  • C27H31Br2ClN4O2
Legacy_Concept_Name
  • Lonafarnib
FULL_SYN
  • lonafarnibPTNCI-GLOSSCDR0000277243
  • 4-[2-[4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamideSNNCI
  • SCH-66336SYDTPNSC0719467
  • SarasarBRNCI
  • LONAFARNIBPTFDAIOW153004F
  • SCH 66336PTNCI-GLOSSCDR0000046699
  • SCH66336CNNCI
  • SCH 66336CNNCI
  • 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamidePTDCP50354
  • SCH-66336CNNCI
  • LonafarnibPTNCI
DEFINITION
  • A synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras proteins have been found in a wide range of human cancers. (NCI04)NCI
code
  • C1829
is someValuesFrom of
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