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AttributesValues
rdf:type
rdfs:label
  • eIF2B
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • eIF2B
UMLS_CUI
  • C0606869
ALT_DEFINITION
  • A guanine nucleotide exchange factor that acts to restore EIF-2 to its GTP bound form.MSH2001
Legacy_Concept_Name
  • eIF2B
FULL_SYN
  • eIF2BPTNCI
  • eIF-2BSYNCI
DEFINITION
  • EIF2B is a heteropentameric complex (alpha, beta, gamma, delta, and epsilon subunits) essential for protein synthesis that catalyzes GDP/GTP exchange of its Eukaryotic Initiation Factor 2 substrate (restores GTP bound EIF2). For EIF2 to perform additional rounds of initiation, it must be recycled by GDP/GTP exchange. Thus, EIF2B sustains translation. EIF2B-epsilon contains a putative nucleotide-binding domain that may be involved in nucleotide exchange. EIF2B defects cause VWM. (NCI)NCI
code
  • C18162
is someValuesFrom of
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