About: Yttrium Y 90-DOTA-Biotin     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Yttrium Y 90-DOTA-Biotin
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Yttrium Y 90-DOTA-Biotin
UMLS_CUI
  • C0677849
ALT_DEFINITION
  • A compound that contains the radioisotope yttrium Y 90 linked to the chemical biotin. Biotin is a molecule that binds strongly to the chemical streptavidin. Yttrium Y 90 DOTA-biotin will find tumor cells in the body that have been targeted by an antibody linked to streptavidin and kill them. It is being studied together with CC49-streptavidin in the treatment of cancer.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 365680
PDQ_Closed_Trial_Search_ID
  • 365680
Legacy_Concept_Name
  • _90Y-DOTA-Biotin
FULL_SYN
  • Yttrium Y 90-DOTA-BiotinPTNCI
  • 90Y-DOTA-BiotinSYNCI
  • 90Y-DOTA-biotinPTNCI-GLOSSCDR0000045584
  • yttrium Y 90 DOTA-biotinPTNCI-GLOSSCDR0000393546
DEFINITION
  • A radioconjugate of biotin and yttrium Y 90 (Y-90) linked through the bifunctional macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) with radioimmunotherapy property. Biotin is a water-soluble B-complex vitamin, present in minute amounts in every living cell, while its level in cancerous tissue is higher than that of normal tissue. Y 90-DOTA-Biotin could be used in 3-step pre-targeting radioimmunotherapy that employs a tumor targeting antibody conjugated with streptavidin, the natural ligand of biotin.NCI
code
  • C1808
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