About: Receptor Tyrosine-Protein Kinase ErbB-4     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Receptor Tyrosine-Protein Kinase ErbB-4
equivalentClass
OMIM_Number
  • 600543
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Receptor
Preferred_Name
  • Receptor Tyrosine-Protein Kinase ErbB-4
UMLS_CUI
  • C0214098
Legacy_Concept_Name
  • ERBB4_Receptor_Protein_Tyrosine_Kinase
FULL_SYN
  • erbB4SYNCI
  • ERBB4 Receptor Protein Tyrosine KinaseSYNCI
  • Receptor Tyrosine-Protein Kinase ErbB-4PTNCI
  • c-erbB-4SYNCI
Swiss_Prot
  • Q15303
DEFINITION
  • Receptor tyrosine-protein kinase erbB-4 (1308 aa, 147 kD) is a cell division process protein that is encoded by the human ERBB4 gene and has roles in multicellular organismal development, cell proliferation and signal transduction.NCI
DesignNote
  • ErbB4 heterodimerizes with other type I receptor tyrosine kinases. In the peripheral nervous system, ErbB4 helps regulate glial proliferation and acts as a signaling molecule at the neuromuscular junction. In the mature CNS, ErbB4 is expressed in cerebellar granule cells and in a subset of cells that also express the neurotransmitter: aminobutyric acid. ErbB4 is critical in cardiac development. It is overexpressed frequently in several common solid tumors, including in breast cancer.
code
  • C17685
is Has_Target of
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