About: Mitogen-Activated Protein Kinase 1     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Mitogen-Activated Protein Kinase 1
equivalentClass
OMIM_Number
  • 176948
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • Mitogen-Activated Protein Kinase 1
UMLS_CUI
  • C0170168
Legacy_Concept_Name
  • Mitogen-Activated_Protein_Kinase-1
FULL_SYN
  • EC 2.7.11.24SYNCI
  • ERT1SYNCI
  • MAPK1SYNCI
  • PRKM1SYNCI
  • MAP Kinase Isoform p42SYNCI
  • MAP Kinase 1SYNCI
  • MAP Kinase 2SYNCI
  • Mitogen-Activated Protein Kinase 1PTNCI
  • Mitogen-Activated Protein Kinase 2SYNCI
  • ERK-2SYNCI
  • MAPK 1SYNCI
  • MAPK 2SYNCI
  • Extracellular Signal-Regulated Kinase 2SYNCI
  • p42MAPKSYNCI
  • p42-MAPKSYNCI
Swiss_Prot
  • P28482
DEFINITION
  • Mitogen-activated protein kinase 1 (390 aa, ~41 kDa) is encoded by the human MAPK1 gene. This protein plays a role in cell cycle regulation, signal transduction, transcriptional regulation and serine/threonine phosphorylation.NCI
DesignNote
  • When MAPK1 is autophosphorylated or phosphorylated/activated by upstream kinases on threonine and tyrosine residues, it forms dimers with phosphorylated and unphosphorylated ERK partners, translocates to the nucleus and phosphorylates target transcription factors.
code
  • C17589
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