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AttributesValues
rdf:type
rdfs:label
  • I Kappa B
rdfs:subClassOf
Semantic_Type
  • Immunologic Factor
Preferred_Name
  • I Kappa B
UMLS_CUI
  • C0167954
ALT_DEFINITION
  • Family of inhibitory proteins which bind to the rel family of transcription factors and modulate their activity. The transcription factor NF-KAPPA B is generally present in an inactive cytoplasmic form, bound to inhibitory IkB proteins. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus.MSH2001
Legacy_Concept_Name
  • I-Kappa-B_Protein
FULL_SYN
  • NFKB InhibitorSYNCI
  • IKBSYNCI
  • NFKBISYNCI
  • NF-Kappa B InhibitorSYNCI
  • I Kappa BPTNCI
DEFINITION
  • Interacting with p65 (RELA), widely expressed 36-38kDa unphosphorylated cytoplasmic ANK-repeat human I Kappa B Proteins A/B/E (NFKBI Family) inhibit NF-Kappa-B, trapping it in the cytoplasm. By complexing with NFKB, IKBs regulate NFKB transcription in cell adhesion, immune and proinflammatory responses, apoptosis, differentiation, and growth. Cytokine-activated serine phosphorylation of IKBs by IKBKA/IKBKB disables the NFKB inhibition by dissociation; promotes polyubiquitinated proteasome-dependent IKB degradation; and allows NFKB nuclear translocation, binding at kappa-B DNA motifs, and target gene transcription. (NCI)NCI
code
  • C17583
is rdf:first of
is someValuesFrom of
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