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AttributesValues
rdf:type
rdfs:label
  • Retinoic Acid Receptor
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Receptor
Preferred_Name
  • Retinoic Acid Receptor
UMLS_CUI
  • C0140278
ALT_DEFINITION
  • Proteins in the nucleus or cytoplasm that specifically bind retinoic acid or retinol and trigger changes in the behavior of cells. Retinoic acid receptors, like steroid receptors, are ligand-activated transcription regulators. Several types have been recognized.MSH2001
Legacy_Concept_Name
  • Retinoic_Acid_Receptor
FULL_SYN
  • Retinoic Acid ReceptorPTNCI
  • Nuclear Receptor Subfamily 1 Group BSYNCI
  • RARABNCI
  • Retinoid ReceptorSYNCI
DEFINITION
  • Retinoid receptors (RARA, RARB, RARG) require co-regulators to increase selective binding to DNA response elements in target genes and enhance transcriptional activity.NCI
DesignNote
  • A protein that binds retinoic acid with high affinity. Binding of ligand to RARs attracts co-activator proteins containing a NR box. NCOR1 and SMRT contain CoRNR box sequences, similar to the NR box, in receptor interaction domains and mediate inhibition of gene transcription by RARs. Sequences flanking the CoRNR box determine receptor specificity. Differential recognition of receptors by co-activators and co-repressors is due to subtle differences between CoRNR and NR boxes. The association of SMRT with receptors is destabilized by ligand, triggering the activation process. (from OMIM 180240 and NCI)
code
  • C17532
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is someValuesFrom of
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