About: Insulin-Like Growth Factor Receptor     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Insulin-Like Growth Factor Receptor
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Receptor
Preferred_Name
  • Insulin-Like Growth Factor Receptor
UMLS_CUI
  • C0140079
ALT_DEFINITION
  • A protein found on the surface of some types of cells that binds to insulin-like growth factor (IGF). This causes the cells to grow and divide. Insulin-like growth factor receptor is found at high levels on the surface of several types of cancer cells, which causes these cells to grow rapidly in the presence of IGF.NCI-GLOSS
  • Cell surface receptors that bind somatomedins and trigger intracellular changes which influence the behavior of cells. Studies have disclosed two types of receptors for this family of peptide hormones. The type I receptor is homologous to the insulin receptor and has tyrosine kinase activity. The type II receptor is identical to the mannose-6-phosphate receptor which is important in trafficking of lysosomal enzymes.MSH2001
Legacy_Concept_Name
  • Insulin-Like_Growth_Factor_Receptor
FULL_SYN
  • IGF ReceptorSYNCI
  • IGFRPTNCI-GLOSSCDR0000653124
  • Insulin-Like Growth Factor ReceptorPTNCI
  • insulin-like growth factor receptorPTNCI-GLOSSCDR0000653123
DEFINITION
  • The protein on surface of target cells specific for binding IGF. There are two types of IGF receptor, one of which closely resembles the insulin receptor.NCI
code
  • C17530
is rdf:first of
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