About: Insulin-Like Growth Factor Binding Protein 4     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Insulin-Like Growth Factor Binding Protein 4
equivalentClass
OMIM_Number
  • 146733
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Biologically Active Substance
Preferred_Name
  • Insulin-Like Growth Factor Binding Protein 4
UMLS_CUI
  • C0123258
Legacy_Concept_Name
  • Insulin-Like_Growth_Factor-Binding_Protein-4
FULL_SYN
  • Insulin-Like Growth Factor Binding Protein 4PTNCI
  • Insulin-Like Growth Factor-Binding Protein 4SYNCI
  • IGFBP4SYNCI
  • IGFBP-4SYNCI
  • IGF Binding Protein 4SYNCI
Swiss_Prot
  • P22692
DEFINITION
  • Insulin-like growth factor binding protein 4 (258 aa, 28 kD) is a cellular division process protein that is encoded by the human IGFBP4 gene and has roles in skeletal development, cell proliferation and signal transduction.NCI
DesignNote
  • IGFBP4 belongs to the IGFBP family. IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis and the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism. IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs. Secreted IGFBPs prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs. They alter the interaction of IGFs with cell surface receptors. IGFBP4 contains a thyroglobulin type-I domain and binds IGF-II more than IGF-I. IGFBP4 inhibits IGF-induced bone cell proliferation. (from OMIM 146733, SWISS-PROT P22692, and NCI)
code
  • C17507
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