About: Cytotoxic T-Lymphocyte-Associated Protein 4     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Cytotoxic T-Lymphocyte-Associated Protein 4
equivalentClass
OMIM_Number
  • 123890
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Cytotoxic T-Lymphocyte-Associated Protein 4
UMLS_CUI
  • C0111208
Legacy_Concept_Name
  • Cytotoxic_T-Lymphocyte-Associated_Protein-4
FULL_SYN
  • CD152 AntigenSYNCI
  • Cytotoxic T-Lymphocyte Protein 4SYNCI
  • Cytotoxic T-Lymphocyte-Associated Antigen 4SYNCI
  • Cytotoxic T-Lymphocyte-Associated Protein 4PTNCI
  • CTLA4 ProteinSYNCI
  • CD152SYNCI
  • CTLA4SYNCI
  • CTLA-4SYNCI
  • CTLA4-TMSYNCI
  • Cytotoxic T-Lymphocyte-Associated Serine Esterase-4SYNCI
Swiss_Prot
  • P16410
DEFINITION
  • CTLA-4 is an inhibitory T-cell surface receptor for B7 ligands on antigen presenting cells. It contains an extracellular V-like domain, a transmembrane region, and a putative cytoplasmic domain. It shares significant homology with CD28. Both bind the same ligands, however CTLA-4 binds to B7 with a greater affinity. B7 antigen-presenting cells regulate T-cell activation by delivering antigen-independent stimulatory signals through CD28 and inhibitory signals through CTLA-4. While CD28 is on the membrane of resting T-cells, CTLA-4 is detectable only on cells activated after antigen presentation. A CTLA-4 splice variant with a deleted transmembrane segment is preferentially expressed in non-activated T-cells. Activation of lymphocytes results in the disappearance of sCTLA-4 followed by its gradual reappearance, whereas CTLA-4 increases after activation. CTLA-4 may play an inhibitory role in regulating lymphocyte expansion. (from OMIM 123890 and NCI)NCI
code
  • C17489
is Has_Target of
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