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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Telomerase
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • Telomerase
UMLS_CUI
  • C0087071
ALT_DEFINITION
  • An enzyme in cells that helps keep them alive by adding DNA to telomeres (the ends of chromosomes). Each time a cell divides, the telomeres lose a small amount of DNA and become shorter. Over time, the chromosomes become damaged and the cells die. Telomerase helps keep this from happening. Cancer cells usually have more telomerase than most normal cells.NCI-GLOSS
  • nonEC; reverse transcriptase like ribonucleoprotein that maintains the telomere sequence; expressed in tumor cells but not in normal cells.CSP2000
  • Essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic chromosomes. Telomerase appears to be repressed in normal human somatic tissues but reactivated in cancer, and thus may be necessary for malignant transformation. EC 2.7.7.-.MSH2001
Legacy_Concept_Name
  • Telomerase
FULL_SYN
  • telomerasePTNCI-GLOSSCDR0000643089
  • TelomerasePTNCI
DEFINITION
  • A reverse transcriptase responsible for maintaining the telomere length of replicating cells. Telomerase recognizes a telomere-specific GC rich sequence and adds telomeric repeats by using and RNA template.NCI
code
  • C17470
is someValuesFrom of
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