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AttributesValues
rdf:type
rdfs:label
  • Vinculin
equivalentClass
OMIM_Number
  • 193065
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Biologically Active Substance
Preferred_Name
  • Vinculin
UMLS_CUI
  • C0085175
ALT_DEFINITION
  • A cytoskeletal protein associated with cell-cell and cell-matrix interactions. The amino acid sequence of human vinculin has been determined. The protein consists of 1066 amino acid residues and its gene has been assigned to chromosome 10.MSH2001
  • actin-binding structural protein which serves to link microfilaments to other organelles in a variety of cell types.CSP2000
Legacy_Concept_Name
  • Vinculin
FULL_SYN
  • VCLSYNCI
  • VinculinPTNCI
Swiss_Prot
  • P18206
DEFINITION
  • Encoded by a single human tumor suppressor VCL Gene, Vinculin contains 1,066 amino acids with strong similarity to other vinculins and alpha-catenins. Alternative splice product metavinculin contains additional 68-79 variable and highly conserved amino acids near the C-terminus. Involved in cell adhesion, vinculin is associated with the cytoplasmic face of adherens-type junctions and involved in anchoring F-actin to the plasma membrane. Vinculin is phosphorylated on serines, threonines and tyrosines and is acylated by myristic acid and/or palmitic acid. Vinculin exhibits self-association properties and appears to be the major talin-binding protein in platelets; 150 kD metavinculin also interacts strongly with talin. (OMIM, Swiss-Prot, LocusLink, and NCI)NCI
code
  • C17430
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