About: Methotrexate Sodium     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Methotrexate Sodium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Methotrexate Sodium
UMLS_CUI
  • C0949359
CAS_Registry
  • 7413-34-5
FDA_UNII_Code
  • 3IG1E710ZN
Contributing_Source
  • FDA
Chemical_Formula
  • C20H20N8O5.2Na
Legacy_Concept_Name
  • Sodium_Methotrexate
CHEBI_ID
  • CHEBI:50679
FULL_SYN
  • Sodium MethotrexateSYNCI
  • Methotrexate SodiumPTNCI
  • METHOTREXATE SODIUMPTFDA3IG1E710ZN
DEFINITION
  • The sodium salt of methotrexate, an antimetabolite with antineoplastic and immunomodulating properties. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant properties. (NCI04)NCI
code
  • C1735
is Has_Salt_Form of
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