About: Cytochrome P450 2D6

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Attributes	Values
rdf:type	Class
rdfs:label	Cytochrome P450 2D6
equivalentClass	nodeID://b631776
OMIM_Number	124030
Semantic_Type	Amino Acid, Peptide, or Protein Enzyme
Preferred_Name	Cytochrome P450 2D6
UMLS_CUI	C0057223
Legacy_Concept_Name	Cytochrome-P450-2D6
FULL_SYN	EC 1.14.14.1SYNCI Flavoprotein-Linked MonooxygenaseSYNCI Microsomal MonooxygenaseSYNCI Cytochrome P450 Subfamily IID Polypeptide 6SYNCI Xenobiotic MonooxygenaseSYNCI Cytochrome P450, Subfamily IID-Like 1SYNCI Debrisoquine 4-HydroxylaseSYNCI CYP2D6SYNCI P450DB1SYNCI CYPIID6SYNCI Cytochrome P450 2D6PTNCI Cytochrome P450-DB1SYNCI Cytochrome P450, Subfamily IIDSYNCI P450-2D6SYNCI P450-DB1SYNCI
Swiss_Prot	P10635
DEFINITION	Cytochrome P450 2D6 (497 aa, ~56 kDa) is encoded by the human CYP2D6 gene. This protein plays a role in flavoprotein metabolism.NCI
DesignNote	Cytochrome P450 2D6 localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrhythmic drugs; and amitriptyline, an anti-depressant.
code	C17287
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