About: Ribonucleotide Reductase

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Attributes	Values
rdf:type	Class
rdfs:label	Ribonucleotide Reductase
rdfs:subClassOf	Protein or Riboprotein Complex nodeID://b709268 nodeID://b709269
Semantic_Type	Amino Acid, Peptide, or Protein Enzyme
Preferred_Name	Ribonucleotide Reductase
UMLS_CUI	C0035547
ALT_DEFINITION	interconverts ribonucleotides (RNA precursors) and deoxyribonucleotides (DNA precursors) rate limiting to DNA replication in rapidly dividing cells, and therefore a potential target of antineoplastic drugs.CSP2000
Legacy_Concept_Name	Ribonucleotide_Reductase
FULL_SYN	Ribonucleotide ReductasePTNCI EC 1.17.4.-SYNCI
DEFINITION	Ribonucleotide Reductase is a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. It consists of two subunits, M1 Chain and M2 Chain. Complex allosteric control, mediated by deoxynucleoside triphosphates, and by ATP bound to the M1 subunit prevents DNA replication and cell proliferation. A substrate specificity site and a catalytic activity site regulate enzyme activity. A substrate-binding catalytic site on M1 is only formed in the presence of M2. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. (NCI)NCI
code	C17101
is someValuesFrom of	nodeID://b673278 nodeID://b673801 nodeID://b676629 nodeID://b676663 nodeID://b676671 nodeID://b676676 nodeID://b676680 nodeID://b676706 nodeID://b680787 nodeID://b698180 nodeID://b709253 nodeID://b709264 nodeID://b709271 nodeID://b720972
is Has_Target of	Triapine

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