About: Thyroid Hormone Receptor     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Thyroid Hormone Receptor
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Receptor
Preferred_Name
  • Thyroid Hormone Receptor
UMLS_CUI
  • C0034843
ALT_DEFINITION
  • Proteins, usually found in the nucleus, that specifically bind thyroid hormones and regulate DNA transcription. These proteins, termed c-erbA, are activated by hormones and cause differentiation of erythroid progenitor cells which irreversibly lose proliferative potential. Thus c-erbA proteins act as growth suppressors. The c-erbA proteins are encoded by at least two genes, c-erbA alpha and c-erbA beta. Each of these has two isoforms. Mutations in the ligand-binding domain of the beta form causes THYROID HORMONE RESISTANCE SYNDROME.MSH2001
Legacy_Concept_Name
  • Thyroid_Hormone_Receptor
FULL_SYN
  • Thyroid Hormone ReceptorPTNCI
  • Nuclear Receptor Subfamily 1 Group ASYNCI
DEFINITION
  • A nuclear receptor that specifically binds to and is activated by thyroid hormone.NCI
code
  • C17078
is rdf:first of
is someValuesFrom of
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