About: Rituximab

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Attributes	Values
rdf:type	Class
rdfs:label	Rituximab
equivalentClass	nodeID://b638133
Has_Target	Antigens, CD20
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Amino Acid, Peptide, or Protein Immunologic Factor
Preferred_Name	Rituximab
NSC_Code	687451
UMLS_CUI	C0732355
CAS_Registry	174722-31-7
Accepted_Therapeutic_Use_For	Diffuse Large B-cell, CD20-positive, Non-Hodgkins Lymphoma
In_Clinical_Trial_For	Non-Hodgkins lymphoma; indolent follicular lymphoma; chronic lymphocytic leukemia, or other B-cell tumors; progressive large cell lymphoma; acute lymphoblastic leukemia; central nervous system lymphoma
FDA_UNII_Code	4F4X42SYQ6
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat certain types of B-cell non-Hodgkin lymphoma. It is also used with other drugs to treat chronic lymphocytic leukemia and rheumatoid arthritis. It is being studied in the treatment of other types of cancer and other conditions. Rituximab binds to a protein called CD20, which is found on B-cells, and may kill cancer cells. It is a type of monoclonal antibody.NCI-GLOSS
PDQ_Open_Trial_Search_ID	42613
PDQ_Closed_Trial_Search_ID	42613
Legacy_Concept_Name	Rituximab
CHEBI_ID	CHEBI:64357
FULL_SYN	C2B8 Monoclonal AntibodySYNCI Chimeric Anti-CD20 AntibodySYNCI RITUXIMABPTFDA4F4X42SYQ6 IDEC-C2B8 Monoclonal AntibodySYNCI Monoclonal Antibody IDEC-C2B8SYNCI RituxanPTNCI-GLOSSCDR0000505945 RituxanBRNCI IDEC-102CNNCI MabTheraFBNCI IDEC-C2B8CNNCI RituximabPTNCI rituximabPTNCI-GLOSSCDR0000045525 RituximabSYNCITCGA
DEFINITION	A recombinant chimeric murine/human antibody directed against the CD20 antigen, a hydrophobic transmembrane protein located on normal pre-B and mature B lymphocytes. Following binding, rituximab triggers a host cytotoxic immune response against CD20-positive cells. (NCI04)NCI
code	C1702
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