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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Trabectedin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Trabectedin
NSC_Code
  • 648766
UMLS_CUI
  • C1311070
CAS_Registry
  • 114899-77-3
In_Clinical_Trial_For
  • Ewings family of tumors; leiomyosarcoma; liposarcoma; prostate cancer; soft tissue sarcoma
FDA_UNII_Code
  • ID0YZQ2TCP
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that comes from a type of sea squirt and is being studied in the treatment of cancer. It binds to DNA and causes breaks in the DNA. It also blocks the ability of the cell to repair the DNA damage, and may cause cancer cells to die. Trabectedin is also made in the laboratory. It is a type of DNA excision repair inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42577
PDQ_Closed_Trial_Search_ID
  • 42577
Chemical_Formula
  • C39H43N3O11S
Legacy_Concept_Name
  • Ecteinascidin_743
FULL_SYN
  • ecteinascidin 743PTNCI-GLOSSCDR0000045516
  • TrabectedinPTNCI
  • trabectedinPTNCI-GLOSSCDR0000543514
  • EcteinascidinSYNCI
  • ET-743PTNCI-GLOSSCDR0000543513
  • Ecteinascidin 743SYNCI
  • ET-743ABNCI
  • Ecteinascidin 743SYDTPNSC0648766
  • YondelisFBNCI
  • TRABECTEDINPTFDAID0YZQ2TCP
DEFINITION
  • A tetrahydroisoquinoline alkaloid isolated from the marine tunicate Ecteinascidia turbinata with potential antineoplastic activity. Binding to the minor groove of DNA, trabectedin interferes with the transcription-coupled nucleotide excision repair machinery to induce lethal DNA strand breaks and blocks the cell cycle in the G2 phase.NCI
code
  • C1691
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