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AttributesValues
rdf:type
rdfs:label
  • Complement
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Complement
UMLS_CUI
  • C0009498
ALT_DEFINITION
  • system of serum proteins that interact with antigen antibody complex to produce cytolytic, chemotaxic, anaphylactic, and other effects.CSP2000
Legacy_Concept_Name
  • Complement
FULL_SYN
  • ComplementPTNCI
DEFINITION
  • The complement system is a complex system of serum proteins that interact in a cascade. Many of the early components are serine proteases that activate each other sequentially. This complement system consists of three separate activation triggers: (1) Ab binding to a cell surface, (2) formation of immune complexes, and (3) a carbohydrate component of a microbe's cell membrane. Along with this triggers, there are also two sets of mechanisms. Both of these mechanisms, classical pathway and alternative or properdin pathway, make MAC (Membrane Attack Complex), which can lyse and destroy the cell.NCI
code
  • C16459
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