About: Mitogen-Activated Protein Kinase

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Attributes	Values
rdf:type	Class
rdfs:label	Mitogen-Activated Protein Kinase
rdfs:subClassOf	Protein-Serine-Threonine Kinases nodeID://b693221 nodeID://b693222 nodeID://b693223 nodeID://b693224 nodeID://b693225 nodeID://b693226
Semantic_Type	Amino Acid, Peptide, or Protein Enzyme
Preferred_Name	Mitogen-Activated Protein Kinase
UMLS_CUI	C0752312
Legacy_Concept_Name	Mitogen-Activated_Protein_Kinase
FULL_SYN	ERKSYNCI Mitogen-Activated Protein KinasePTNCI MAPKABNCI Extracellular Signal-Regulated KinasesSYNCI EC 2.7.2-SYNCI Map KinaseSYNCI
DEFINITION	Mitogen-activated protein kinases (MAPKs) are serine-threonine protein kinases activated in response to a variety of extracellular stimuli and encoded by a multigene family. The MAPKs are part of complex protein kinase cascades. One of the several classes of MAPKs includes (among other ERKs) the extracellular signal-regulated kinases ERK1 (p44MAPK) and ERK2 (p42MAPK), activated by the RAF/MEK/ERK signaling pathway. ERK1/2 are widely involved in eukaryotic signal transduction. Upon activation, ERKs translocate to the nucleus and phosphorylate nuclear targets. Phosphorylated ERKs form essential dimers with phosphorylated and unphosphorylated ERK partners. Dimerization is part of the mechanism of MAP kinase family action. Mitogen-activated protein kinases (MAPKs) promote entry in the cell cycle. (from OMIM 601795, 176948, Swiss-Prot P27361, P28482 and NCI)NCI
code	C16376
is rdf:first of	nodeID://b736758 nodeID://b736759 nodeID://b736760 nodeID://b736761 nodeID://b736762 nodeID://b736763 nodeID://b736764 nodeID://b736765 nodeID://b736766 nodeID://b736767 nodeID://b736768 nodeID://b736769 nodeID://b736770
is someValuesFrom of	nodeID://b688121 nodeID://b688148 nodeID://b688172 nodeID://b688199 nodeID://b688227 nodeID://b693324 nodeID://b717007

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