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AttributesValues
rdf:type
rdfs:label
  • Labradimil
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Labradimil
NSC_Code
  • 950021
UMLS_CUI
  • C0289630
CAS_Registry
  • 159768-75-9
FDA_UNII_Code
  • 2MK663C346
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied for its ability to help other drugs reach the brain. It belongs to the family of drugs called bradykinin agonists.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42352
PDQ_Closed_Trial_Search_ID
  • 42352
Chemical_Formula
  • C49H75N15O12S
Legacy_Concept_Name
  • Lobradimil
FULL_SYN
  • lobradimilSYNCI-GLOSSCDR0000367477
  • L-Prolinamide, L-Arginyl-L-prolyl-trans-4- hydroxy-L-prolyl-3-(2- thienyl)-L-alanylglycl -L-seryl-N-(2-((4-((aminoiminomethyl)amino)-1- -carboxybutyl)amino)-1-((4-methoxyphenyl)methyl)ethyl)-, (S-(R*,R*))SNNCI
  • RMP-7SYNCI-GLOSSCDR0000045461
  • LABRADIMILPTFDA2MK663C346
  • DRG-0182CNNCI
  • CereportBRNCI
  • LabradimilPTNCI
  • LobradimilSYNCI
DEFINITION
  • A synthetic analog of bradykinin. Lobradimil is a potent, specific bradykinin B-2 receptor agonist that stimulates B-2 receptors expressed on the surface of brain capillary endothelial cells, thereby reversibly increasing the permeability of the blood-brain barrier (BBB). Compared to bradykinin, this agent possesses enhanced receptor selectivity, greater plasma stability, and a longer half-life. (NCI04)NCI
code
  • C1606
is someValuesFrom of
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