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AttributesValues
rdf:type
rdfs:label
  • Tallimustine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Tallimustine
UMLS_CUI
  • C0286890
CAS_Registry
  • 115308-98-0
FDA_UNII_Code
  • 71193OXG6S
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 42145
PDQ_Closed_Trial_Search_ID
  • 42145
Chemical_Formula
  • C32H38Cl2N10O4
Legacy_Concept_Name
  • Tallimustine
FULL_SYN
  • TALLIMUSTINEPTFDA71193OXG6S
  • TallimustinePTNCI
  • FCE 24517CNNCI
  • PNU-152241CNNCI
DEFINITION
  • A benzoyl mustard derivative of the antiviral agent distamycin A with potential antineoplastic activity. Tallimustine selectively binds to A-T rich regions in the minor groove of DNA and alkylates at the N3 position of adenine in a highly sequence-specific manner. This prevents DNA replication, inhibits cellular proliferation and triggers apoptosis. Moreover, unlike other clinical nitrogen mustards, tallimustine does not carry out guanine-N7 alkylation in the major groove of DNA, which may lead to a high selectivity of action.NCI
code
  • C1603
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