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AttributesValues
rdf:type
rdfs:label
  • Dexverapamil
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Dexverapamil
UMLS_CUI
  • C0280858
CAS_Registry
  • 38321-02-7
FDA_UNII_Code
  • QR5PYD126V
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 41269
PDQ_Closed_Trial_Search_ID
  • 41269
Chemical_Formula
  • C27H38N2O4
Legacy_Concept_Name
  • Dexverapamil
FULL_SYN
  • DEXVERAPAMILPTFDAQR5PYD126V
  • R VerapamilSYNCI
  • R-VerapamilSYNCI
  • DexverapamilPTNCI
DEFINITION
  • The R-enantiomer of the calcium channel blocker verapamil. Dexverapamil competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. This agent exhibits decreased calcium antagonistic activity and toxicity compared to racemic verapamil. (NCI04)NCI
code
  • C1563
is someValuesFrom of
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