About: Recombinant Interleukin-15     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant Interleukin-15
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Recombinant Interleukin-15
UMLS_CUI
  • C1522569
PDQ_Open_Trial_Search_ID
  • 661035
PDQ_Closed_Trial_Search_ID
  • 661035
Legacy_Concept_Name
  • Therapeutic_Interleukin-15
FULL_SYN
  • Interleukin 15SYNCI
  • Recombinant Interleukin-15PTNCI
  • IL15ABNCI
DEFINITION
  • A recombinant agent that is chemically identical or similar to the endogenous cytokine interleukin-15 (IL-15) with immunomodulating activity. IL-15, secreted by mononuclear phagocytes (and some other cell types) following viral infection, regulates T and natural killer cell activation and proliferation. This cytokine induces activation of transcription activators STAT3, STAT5, and STAT6 via JAK kinase signal transduction pathways in mast cells, T cells, and dendritic epidermal T cells. IL-15 and interleukin-2 (IL-2) are structurally similar and share many biological activities; both may bind to common hematopoietin receptor subunits, negatively regulating each other's activity. CD8+ memory T cell number has been shown to be regulated by a balance between IL-15 and IL-2.NCI
code
  • C1545
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