About: Tezacitabine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Tezacitabine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Tezacitabine
UMLS_CUI
  • C0253087
CAS_Registry
  • 171176-43-5
FDA_UNII_Code
  • UCC4EQS7WL
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that belongs to a family of drugs called ribonucleotide reductase inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 354256
PDQ_Closed_Trial_Search_ID
  • 354256
Chemical_Formula
  • C10H12FN3O4.H2O
Legacy_Concept_Name
  • Tezacitabine
FULL_SYN
  • TezacitabinePTNCI
  • 2'-Deoxy-2'-(fluoromethylene)cytidineSNNCI
  • FMdCABNCI
  • MDL 101,731CNNCI
  • MDL 101,731PTNCI-GLOSSCDR0000045472
  • TEZACITABINEPTFDAUCC4EQS7WL
DEFINITION
  • A synthetic pyrimidine nucleoside analogue with potential antineoplastic activity. Phosphorylated by cellular kinases, tezacitabine is converted into its active diphosphate and triphosphate metabolites. Tezacitabine diphosphate binds to and irreversibly inhibits the activity of the enzyme ribonucleotide reductase (RNR), which may result in the inhibition of DNA synthesis in tumor cells and tumor cell apoptosis. Tezacitabine triphosphate acts as a substrate for DNA polymerase, further compromising DNA replication. This agent is relatively resistant to metabolic deactivation by cytidine deaminase. RNR catalyzes the conversion of ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates necessary for DNA synthesis and is overexpressed in many tumor types.NCI
code
  • C1539
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