About: Pemetrexed Disodium     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Pemetrexed Disodium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Pemetrexed Disodium
NSC_Code
  • 698037
UMLS_CUI
  • C1101816
CAS_Registry
  • 150399-23-8
Accepted_Therapeutic_Use_For
  • Malignant pleural mesothelioma; Non-small cell lung cancer
FDA_UNII_Code
  • 2PKU919BA9
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used alone or with another drug to treat certain types of non-small cell lung cancer and malignant pleural mesothelioma. It is being studied in the treatment of other types of cancer. Pemetrexed disodium blocks DNA synthesis and may kill cancer cells. It is a type of folate antagonist.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42328
PDQ_Closed_Trial_Search_ID
  • 42328
Chemical_Formula
  • C20H19N5O6.2Na
Legacy_Concept_Name
  • Pemetrexed
CHEBI_ID
  • CHEBI:63722
FULL_SYN
  • N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium SaltPTDCP50621
  • N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium SaltSNNCI
  • pemetrexed disodiumPTNCI-GLOSSCDR0000045456
  • AlimtaPTNCI-GLOSSCDR0000410734
  • LY231514PTNCI-GLOSSCDR0000044358
  • AlimtaBRNCI
  • LY231514CNNCI
  • Pemetrexed DisodiumPTNCI
  • PEMETREXED DISODIUMPTFDA2PKU919BA9
DEFINITION
  • The disodium salt of a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.NCI
code
  • C1533
is someValuesFrom of
is Has_Salt_Form of
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