About: Intoplicine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Intoplicine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Intoplicine
PubMedID_Primary_Reference
  • 12570767
NSC_Code
  • 645008
UMLS_CUI
  • C0217476
CAS_Registry
  • 125974-72-3
FDA_UNII_Code
  • FB2CIN6HMI
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that has been studied in the treatment of some types of cancer. Intoplicine blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of topoisomerase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43318
PDQ_Closed_Trial_Search_ID
  • 43318
Chemical_Formula
  • C21H24N4O
Legacy_Concept_Name
  • Intoplicine
FULL_SYN
  • IntoplicineSYDTPNSC0645008
  • IntoplicinePTNCI
  • 7H-benzo(e)pyrido(4,3-b)indol-3-ol, 11-((3-(dimethylamino)propyl)amino)-8-methylSNNCI
  • intoplicinePTNCI-GLOSSCDR0000046164
  • INTOPLICINEPTFDAFB2CIN6HMI
DEFINITION
  • A benzopyridoindole derivative with antineoplastic property. Intoplicine inhibits activities of both topoisomerase I and II via intercalating DNA helix, thereby hindering the movements of enzymes along DNA molecules during DNA transcription and replication, respectively. Furthermore, this agent stabilizes DNA-enzyme complexes during unwinding processes by both topoisomerases, leading to double- and single-stranded DNA breaks. Consequently, these effects bring about cell growth inhibition and apoptosis of tumor cells.NCI
code
  • C1495
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