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AttributesValues
rdf:type
rdfs:label
  • Aminocamptothecin
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Aminocamptothecin
NSC_Code
  • 603071
UMLS_CUI
  • C0214192
CAS_Registry
  • 86639-63-6
ALT_DEFINITION
  • An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 41792
PDQ_Closed_Trial_Search_ID
  • 41792
Legacy_Concept_Name
  • Aminocamptothecin
FULL_SYN
  • 9-amino-CPTSYNCI
  • 9-Amino-20-(S)-camptothecinSYDTPNSC0603071
  • 9-amino-20-camptothecinSNNCI
  • aminocamptothecinPTNCI-GLOSSCDR0000045399
  • 9-amino-20(S)-camptothecinSNNCI
  • 9-ACABNCI
  • AminocamptothecinPTNCI
  • 9-aminocamptothecinSYNCI
  • 9-amino-camptothecinSYNCI
  • 9-ACSYDTPNSC0603071
DEFINITION
  • A water-insoluble camptothecin derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand DNA breakages. Because the terminal lactone ring of aminocamptothecin required for the agent's antitumor activity spontaneously opens under physiological conditions to an inactive carboxy form, the drug must be administered over an extended period of time to achieve effective cytotoxicity. (NCI04)NCI
code
  • C1488
is someValuesFrom of
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