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AttributesValues
rdf:type
rdfs:label
  • Rubitecan
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Rubitecan
NSC_Code
  • 603070
UMLS_CUI
  • C0213800
CAS_Registry
  • 91421-42-0
Accepted_Therapeutic_Use_For
  • AIDs, pediatric; HIV infection, pediatric
In_Clinical_Trial_For
  • Metastatic ovarian epithelial or primary peritoneal cancer
FDA_UNII_Code
  • H19C446XXB
Contributing_Source
  • FDA
ALT_DEFINITION
  • An alkaloid drug belonging to a class of anticancer agents called topoisomerase inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42528
PDQ_Closed_Trial_Search_ID
  • 42528
Chemical_Formula
  • C20H15N3O6
Legacy_Concept_Name
  • Rubitecan
FULL_SYN
  • nitrocamptothecinPTNCI-GLOSSCDR0000045502
  • 9-Nitro-20(S)-camptothecinSNNCI
  • 9-NCABNCI
  • NitrocamptothecinSYNCI
  • RUBITECANPTFDAH19C446XXB
  • RFS 2000CNNCI
  • 9-nitrocamptothecinSYNCI
  • CamptogenBRNCI
  • OrathecinBRNCI
  • RubitecanPTNCI
DEFINITION
  • A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks. (NCI04)NCI
code
  • C1485
is someValuesFrom of
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