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AttributesValues
rdf:type
rdfs:label
  • Loxoribine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • Loxoribine
UMLS_CUI
  • C0209660
CAS_Registry
  • 121288-39-9
FDA_UNII_Code
  • 9CAS0V66OI
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 41358
PDQ_Closed_Trial_Search_ID
  • 41358
Chemical_Formula
  • C13H17N5O6
Legacy_Concept_Name
  • Loxoribine
FULL_SYN
  • 7-Allyl-8-oxoguanosineSNNCI
  • LOXORIBINEPTFDA9CAS0V66OI
  • LoxoribinePTNCI
DEFINITION
  • A guanine ribonucleotide derivative with immunostimulatory and immunomodulatory activity. Loxoribine undergoes facilitated transport across the plasma membrane into the cytoplasmic compartment of the cell and acts intracellularly, bypassing the biochemical steps involved in the membrane signal transduction pathway used by Ag or anti-IgM Abs to activate B cells. This agent activates the Toll-like receptor 7 (TLR7), a member of the TLR family of pathogen-associated molecular pattern recognition receptors thereby activating the innate immune system. This activation requires endosomal maturation and recognition is restricted to TLR7. As a result, loxoribine induces cycling B cells to proliferate and differentiate non-specifically and recruit antigen-reactive B cells to undergo differentiation to antibody production, markedly amplifying the underlying response in the process.NCI
code
  • C1470
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