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AttributesValues
rdf:type
rdfs:label
  • Sorivudine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Sorivudine
UMLS_CUI
  • C0207628
CAS_Registry
  • 77181-69-2
FDA_UNII_Code
  • C7VOZ162LV
Contributing_Source
  • FDA
ALT_DEFINITION
  • An antiviral drug that is being studied as a treatment for herpesvirus. It belongs to the family of drugs called nucleic acid synthesis inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 41663
PDQ_Closed_Trial_Search_ID
  • 41663
Chemical_Formula
  • C11H13BrN2O6
Legacy_Concept_Name
  • Sorivudine
FULL_SYN
  • sorivudinePTNCI-GLOSSCDR0000335515
  • 2,4(1H,3H)-pyrimidinedione, 1-beta-D-arabinofuranosyl-5-(2-bromoethenyl)SNNCI
  • (E)-1-beta-D-arabinofuranosyl-5-(2-bromoethenyl)-2,4(1H,3H)-pyrimidinedioneSNNCI
  • YN-72CNNCI
  • 5-Bromovinyl-araUSNNCI
  • UsevirFBNCI
  • (+)-1-Beta-D-arabinofuranosyl-5-[(E)-2-bromovi- ny1] uracilSNNCI
  • 5-(2-bromovinyl)-1-beta-D- arabinofuranosyluracilSNNCI
  • BV-araUABNCI
  • SQ 32756CNNCI
  • SORIVUDINEPTFDAC7VOZ162LV
  • BravavirFBNCI
  • 1-Beta-D-arabinofuranosyl-(E)-5-(2-bromovinyl)uracilSNNCI
  • SorivudinePTNCI
DEFINITION
  • A synthetic thymidine analogue with potent antiviral activity against herpes simplex and varicella zoster viruses. Sorivudine is phosphorylated into triphosphate form within the cells; this metabolite interferes with viral DNA replication by inhibiting DNA polymerase activity without been incorporated into elongating viral DNA. Due to the dangerous effects of drug-drug interactions via its metabolite, sorivudine has been removed from the market.NCI
code
  • C1460
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