About: Recombinant Glial Cell-Line Derived Neurotrophic Factor     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant Glial Cell-Line Derived Neurotrophic Factor
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Recombinant Glial Cell-Line Derived Neurotrophic Factor
UMLS_CUI
  • C1527004
Legacy_Concept_Name
  • Recombinant_Glial_Cell-Line_Derived_Neurotrophic_Factor
FULL_SYN
  • Glial Cell-Line Derived Neurotrophic FactorSYNCI
  • Recombinant Glial Cell-Line Derived Neurotrophic FactorPTNCI
  • GDNFABNCI
DEFINITION
  • A recombinant therapeutic agent which is chemically identical to or similar to endogenous glial cell line-derived neurotrophic factor (GDNF). GDNF is a glycosylated, disulfide-bonded homodimer distantly related member of the transforming growth factor-beta superfamily. This agent is important in the development and maintenance of dopamine neurons, has restorative effects in a wide variety of rodent and primate models of Parkinson disease, and may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons. (NCI04)NCI
code
  • C1459
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