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AttributesValues
rdf:type
rdfs:label
  • Carzelesin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Carzelesin
NSC_Code
  • 619029
UMLS_CUI
  • C0172048
CAS_Registry
  • 119813-10-4
FDA_UNII_Code
  • 668UF07O1P
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anticancer drug that belongs to the family of drugs called alkylating agents.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42571
PDQ_Closed_Trial_Search_ID
  • 42571
Chemical_Formula
  • C41H37ClN6O5
Legacy_Concept_Name
  • Carzelesin
FULL_SYN
  • carzelesinPTNCI-GLOSSCDR0000045515
  • U-80244CNNCI
  • 2-benzofurancarboximide,N-(2-((1-(chloromethyl)-1,6-dihydro-8-methyl-5-(((phenylamino)carbonyl0oxy0benzo(1,2-b:4,3-b')dipyrrol-3(2H0-yl)carbonyl-1H-indol-5-yl)-6-(diethylamino)-,(S)SNNCI
  • CARZELESINPTFDA668UF07O1P
  • CarzelesinSYDTPNSC0619029
  • CarzelesinPTNCI
DEFINITION
  • A cyclopropylpyrroloindole prodrug analogue and DNA minor groove binding agent, with antineoplastic activity. After hydrolysis, the cyclopropyl group of carzelesin alkylates N3-adenine in a sequence-selective fashion. This results in tumor growth inhibition.NCI
code
  • C1441
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