About: Calcium-Binding Domain     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Calcium-Binding Domain
rdfs:subClassOf
Semantic_Type
  • Amino Acid Sequence
Preferred_Name
  • Calcium-Binding Domain
UMLS_CUI
  • C1516143
Legacy_Concept_Name
  • Calcium-Binding_Domain
FULL_SYN
  • Calcium-Binding DomainPTNCI
  • Calcium-Binding MotifSYNCI
DEFINITION
  • Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both side by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1, 3, 5, 7, 9 and 12; these residues are denoted by X, Y, Z, -Y, -X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand). (From InterPro IPR002048)NCI
code
  • C14114
is rdfs:subClassOf of
is someValuesFrom of
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