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AttributesValues
rdf:type
rdfs:label
  • Proline-Rich Domain
rdfs:subClassOf
Semantic_Type
  • Amino Acid Sequence
Preferred_Name
  • Proline-Rich Domain
UMLS_CUI
  • C1514490
Legacy_Concept_Name
  • Proline-Rich_Domain
FULL_SYN
  • Proline-Rich DomainPTNCI
  • Proline-Rich RegionSYNCI
DEFINITION
  • Proline-Rich Domains may be involved in heterotypic protein-protein interactions in signal transduction or other pathways. Found in signaling and structural proteins, WW domains are composed of approximately 40 amino acids folded as a stable, triple stranded beta-sheet that recognize proline-rich sequences. Some WW domains show a remarkable similarity to SH3 domains, which also appear to recognize some proline-rich sequences. Ena/VASP (Drosophila Enabled/Vasodilator-Stimulated Phosphoprotein) Family members regulate actin filament assembly, often through association with binding partners that display a proline-rich FPPPP motif. Ena/VASP proteins interact with these partners via the highly conserved Ena/VASP homology 1 (EVH1) domain. (NCI)NCI
code
  • C14106
is someValuesFrom of
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