About: Carbenicillin Indanyl Sodium

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Attributes	Values
rdf:type	Class
rdfs:label	Carbenicillin Indanyl Sodium
rdfs:subClassOf	EXTENDED SPECTRUM PENICILLINS
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Antibiotic Organic Chemical
Preferred_Name	Carbenicillin Indanyl Sodium
UMLS_CUI	C0142817
CAS_Registry	26605-69-6
Accepted_Therapeutic_Use_For	Urinary tract infections; prostatitis
FDA_UNII_Code	4OUL81K2RT
Contributing_Source	FDA
Chemical_Formula	C26H25N2O6S.Na
Legacy_Concept_Name	Carbenicillin_Indanyl_Sodium
CHEBI_ID	CHEBI:31358
FULL_SYN	CARBENICILLIN INDANYL SODIUMPTFDA4OUL81K2RT Carbenicillin Indanyl SodiumPTNCI GeocillinSYDTPNSC0528986 GeocillinBRNCI
DEFINITION	The sodium salt of indanyl carbenicillin, a broad-spectrum, semi-synthetic carboxypenicillin antibiotic with bactericidal activity. Carbenicillin acylates C-terminal domain of penicillin-sensitive transpeptidase, resulting in opening the lactam ring of the antibiotic. This inactivation prevents the formation of the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. As a result, cell wall integrity is compromised and cell lysis may follow. This agent is used mainly for gram-negative infections, and has limited gram-positive coverage.NCI
code	C1409

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