About: DAG/PE-Binding Domain

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Attributes	Values
rdf:type	Class
rdfs:label	DAG/PE-Binding Domain
rdfs:subClassOf	Ligand Binding Domain
Semantic_Type	Amino Acid Sequence
Preferred_Name	DAG/PE-Binding Domain
UMLS_CUI	C1511644
Legacy_Concept_Name	DAG_PE-Binding_Domain
FULL_SYN	Phorbol Ester Binding DomainSYNCI DAG Binding DomainSYNCI Diacylglycerol Binding DomainSYNCI C1 DomainSYNCI DAG/PE-Binding DomainPTNCI Protein Kinase C Conserved Region 1 DomainSYNCI
DEFINITION	The cysteine-rich N-terminal DAG/PE (Diacylglycerol/Phorbol Ester)-Binding (C1) Domain of PKC isoforms interacts with phorbol ester or with the phospholipid-derived second messenger diacylglycerol. C1 contains one or two copies of a Cys-rich domain about 50 amino-acid residues long; the domain binds two zinc ions, probably involving the conserved cysteines and histidines. Bound to DAG, C1 domains are involved in recruitment of proteins to the membrane via basic residues that interact with lipid head groups. Part of the domain contains two beta sheets that form a cavity and a short C-terminal alpha helix; another contains two zinc-binding sites that maintain the domain fold. Binding of diacylglycerol, or phorbol ester, to the domain results in modification of protein function. (NCI)NCI
code	C14080
is someValuesFrom of	nodeID://b641473 nodeID://b647973 nodeID://b685543 nodeID://b685551 nodeID://b694636 nodeID://b705244 nodeID://b705293 nodeID://b706279 nodeID://b706570 nodeID://b709130 nodeID://b709144 nodeID://b709184 nodeID://b722425

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