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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • ITAM
rdfs:subClassOf
Semantic_Type
  • Amino Acid Sequence
Preferred_Name
  • ITAM
UMLS_CUI
  • C1521889
Legacy_Concept_Name
  • ITAM
FULL_SYN
  • Immunoreceptor Tyrosine-Based Activation MotifSYNCI
  • ARAMSYNCI
  • ITAMPTNCI
  • Ag Recognition Activation MotifSYNCI
  • Immunoreceptor Tyr-Based Activation MotifSYNCI
DEFINITION
  • ITAM (Immunoreceptor Tyrosine-based Activation Motif) or ARAM (Ag Recognition Activation Motif) (Y-X-X-L-(X)6-8-Y-X-X-L), a protein domain involved in STP, binds to SH2 domain, e.g. in CD247/x chain, FceRI g chain, or DAP12. Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases. Motif may be dually phosphorylated on tyrosine that links antigen receptors to downstream signaling machinery.NCIfrom Pfam PF0218 and http://digilander.libero.it/danielefocosi/proteindomains.html
code
  • C14048
is someValuesFrom of
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