About: Prednisolone Sodium Phosphate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Prednisolone Sodium Phosphate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Steroid
Preferred_Name
  • Prednisolone Sodium Phosphate
UMLS_CUI
  • C0138273
CAS_Registry
  • 125-02-0
FDA_UNII_Code
  • IV021NXA9J
Contributing_Source
  • FDA
Chemical_Formula
  • C21H27O8P.2Na
Legacy_Concept_Name
  • Prednisolone_Sodium_Phosphate
CHEBI_ID
  • CHEBI:8379
FULL_SYN
  • Key-Pred SPBRNCI
  • PREDNISOLONE SODIUM PHOSPHATEPTFDAIV021NXA9J
  • Ak-PredBRNCI
  • Prednisolone Sodium PhosphatePTNCI
  • PredmixFBNCI
  • PredsolFBNCI
  • PolypredFBNCI
  • PediapredBRNCI
  • InflamaseBRNCI
  • PrednesolFBNCI
  • PrednisolBRNCI
  • PrednabeneFBNCI
DEFINITION
  • The sodium phosphate salt form of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. As a glucocorticoid receptor agonist, prednisolone sodium phosphate binds to specific intracellular glucocorticoid receptors, and causes the ligand- receptor complex to be translocated to the nucleus where it initiates the transcription of glucocorticoid-responsive genes such as various cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both potent mediators of inflammation. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations.NCI
code
  • C1402
is Has_Salt_Form of
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