About: Zinc-Binding, DNA-Binding Motif     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Zinc-Binding, DNA-Binding Motif
rdfs:subClassOf
Semantic_Type
  • Amino Acid Sequence
Preferred_Name
  • Zinc-Binding, DNA-Binding Motif
UMLS_CUI
  • C1520221
Legacy_Concept_Name
  • Zinc-Binding_DNA-Binding_Motif
FULL_SYN
  • Zinc FingerSYNCI
  • Zinc Finger DomainSYNCI
  • Zinc-Binding, DNA-Binding MotifPTNCI
DEFINITION
  • Zinc-binding, DNA-binding motifs in proteins contain amino acids that are folded into a single DNA-binding structural unit around a zinc atom.NCI
DesignNote
  • The Zinc Finger Domain is found in many proteins that bind nucleic acids, typically DNA binding transcription factors. There are several classes of Zn finger proteins. Some bind Zn with only Cys residues (e.g., nuclear receptor superfamily) while others coordinate Zn with Cys and His residues. In the 25-amino acid C2H2 type motif, Zn2+ is held between a pair of anti-parallel beta strands and a single alpha helix by a pair of invariant Cys and His residues. The Cys/His type proteins generally contain repeated units and bind DNA as a monomer, while Cys/Cys proteins contain two units that bind inverted DNA repeats as homo- or heterodimers. In some Cys/Cys types the Zn ion folds the involved region into a globular structure that binds DNA.
code
  • C13427
is rdfs:subClassOf of
is someValuesFrom of
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