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AttributesValues
rdf:type
rdfs:label
  • Tight Junction
rdfs:subClassOf
Semantic_Type
  • Cell Component
Preferred_Name
  • Tight Junction
UMLS_CUI
  • C0242358
ALT_DEFINITION
  • area of closely apposed plasma membranes of two adjacent animal cells; lateral diffusion of proteins within the lipid bilayer is reduced and intercellular exchange of solutes is enhanced.CSP2000
  • Cell-cell junctions that seal adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. (Alberts et al., Molecular Biology of the Cell, 2nd ed, pG-22)MSH2001
Legacy_Concept_Name
  • Tight_Junction
FULL_SYN
  • Tight JunctionPTNCI
  • Zonula OccludensSYNCI
  • Occluding JunctionSYNCI
DEFINITION
  • Found near the apical surface of cells in simple epithelia. Forms a sealing "gasket" around the cell by the fusion of adjacent cell membranes which encircle the apical cell surface like a belt or fence. Prevents fluid moving through the intercellular gap and the lateral diffusion of intrinsic membrane proteins between apical and basolateral domains of the plasma membrane as well as occludes the movement of solute molecules between cells. Various proteins components of this junction have been identified, but how they are linked to form the ultrastructure of the junction is not known.NCI
code
  • C13333
is someValuesFrom of
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