About: Dexrazoxane

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Dexrazoxane
rdfs:subClassOf	Metal Chelator nodeID://b666643 nodeID://b666644 nodeID://b666645
Has_Salt_Form	DEXRAZOXANE HYDROCHLORIDE
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Dexrazoxane
NSC_Code	169780
UMLS_CUI	C0733406
CAS_Registry	24584-09-6
Accepted_Therapeutic_Use_For	Chemotherapy-induced cardiomyopathy
In_Clinical_Trial_For	Chemoprotection
FDA_UNII_Code	048L81261F
Contributing_Source	FDA
ALT_DEFINITION	The active ingredient in a drug used to treat severe side effects caused by certain anticancer drugs. Under the brand name Totect it is used to treat the toxic effects of an anticancer drug that leaks from a vein into surrounding tissue and causes tissue damage. Under the brand name Zinecard it is used to reduce heart damage in women given doxorubicin for breast cancer that has spread. Dexrazoxane is also being studied in the treatment of cancer. It is a type of cardioprotective agent, a type of chemoprotective agent, and a type of topoisomerase inhibitor.NCI-GLOSS
Chemical_Formula	C11H16N4O4
Legacy_Concept_Name	Dexrazoxane
CHEBI_ID	CHEBI:50223
FULL_SYN	2,6-Piperazinedione, 4, 4'-(1-methyl-1,2-ethanediyl)bis-, (S)- (9CI)SYDTPNSC0169780 DexrazoxanePTNCI dexrazoxanePTNCI-GLOSSCDR0000045220 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-,(S)-(9CI)SNNCI DexrazoxanePTDCP06178 2,6-Piperazinedione, 4,4'propylenedi-,(P)-(8CI)SNNCI 2, 6-Piperazinedione, 4,4'-propylenedi-, (P)- (8CI)SYDTPNSC0169780 ICRF-187SYDTPNSC0169780 Soluble ICRF (L-isomer)SYDTPNSC0169780 Razoxane (+)-formSYNCI ADR-529CNNCI ICRF-187CNNCI (+)-(S)-4,4'-(1-Methyl-1,2-ethanediyl)di(2,6-piperazinedione)SNNCI DEXRAZOXANEPTFDA048L81261F
DEFINITION	A bisdioxopiperazine with iron-chelating, chemoprotective, cardioprotective, and antineoplastic activities. After hydrolysis to an active form that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron, limiting the formation of free radical-generating anthracycline-iron complexes, which may minimize anthracycline-iron complex-mediated oxidative damage to cardiac and soft tissues. This agent also inhibits the catalytic activity of topoisomerase II, which may result in tumor cell growth inhibition.NCI
code	C1333
is someValuesFrom of	nodeID://b647246 nodeID://b647256 nodeID://b651014 nodeID://b651073 nodeID://b659921 nodeID://b662658 nodeID://b662664 nodeID://b662668 nodeID://b662670 nodeID://b666646 nodeID://b666648 nodeID://b666652 nodeID://b666659 nodeID://b666663 nodeID://b666664
is Has_Free_Acid_Or_Base_Form of	DEXRAZOXANE HYDROCHLORIDE

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