About: Helix-Loop-Helix Domain     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Helix-Loop-Helix Domain
rdfs:subClassOf
Semantic_Type
  • Amino Acid Sequence
Preferred_Name
  • Helix-Loop-Helix Domain
UMLS_CUI
  • C0206678
ALT_DEFINITION
  • Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.MSH2001
Legacy_Concept_Name
  • Helix-Loop-Helix_Domain
FULL_SYN
  • Helix-Loop-Helix MotifSYNCI
  • Helix-Loop-Helix DomainPTNCI
  • HLH MotifSYNCI
  • HLH DomainSYNCI
DEFINITION
  • In transcription regulators of cell cycle control, cell determination, and cell differentiation, the conserved HLH (Helix-Loop-Helix) Domain of 40-50 amino acids forms amphipathic helixes between a variable loop. HLHs typically mediate homo- or heterodimerization through interactions with self or other motifs to activate or inactivate trans-activating function. The N-helix often contains DNA-interacting basic residues; the C-helix typically contains characteristically spaced hydrophobic residues. An adjacent basic region of 15 amino acids in most HLH proteins binds to DNA. Basic (b)HLH proteins bind variants of the 'CANNTG' E-box. Proteins lacking the basic domain act as inhibitors, failing to bind DNA. bHLH proteins exhibit specific dimerization partner combinations. In calcium-binding proteins, certain invariant hydrophilic loop residues in the HLH motif bind calcium. (NCI)NCI
code
  • C13313
is rdfs:subClassOf of
is someValuesFrom of
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