About: O6-Benzylguanine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • O6-Benzylguanine
equivalentClass
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • O6-Benzylguanine
NSC_Code
  • 637037
UMLS_CUI
  • C0083812
CAS_Registry
  • 19916-73-5
FDA_UNII_Code
  • 01KC87F8FE
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that may improve the response of cancer cells to chemotherapy.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42113
PDQ_Closed_Trial_Search_ID
  • 42113
Chemical_Formula
  • C12H11N5O
Legacy_Concept_Name
  • O_6_Benzylguanine
FULL_SYN
  • O(6)-benzylguaninePTNCI-GLOSSCDR0000046040
  • 2-amino-6-(phenylmethoxy)-9h-purineSNNCI
  • 2-amino-6-(benzyloxy)purineSNNCI
  • O6-BenzylguanineSNNCI
  • O6-BenzylguaninePTNCI
  • O-6-BenzylguanineSNNCI
  • 6-O-BENZYLGUANINEPTFDA01KC87F8FE
  • O6-BenzylguanineSYDTPNSC0637037
  • O(6)-BenzylguanineSYNCI
  • 6-O-BenzylguanineSYDTPNSC0637037
DEFINITION
  • A guanine analogue with antineoplastic activity. O6-benzylguanine binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), transferring the benzyl moiety to the active-site cysteine and resulting in inhibition of AGT-mediated DNA repair. Co-administration of this agent potentiates the effects of other chemotherapeutic agents that damage DNA. (NCI04)NCI
code
  • C1306
is someValuesFrom of
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