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AttributesValues
rdf:type
rdfs:label
  • Trofosfamide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Trofosfamide
NSC_Code
  • 109723
UMLS_CUI
  • C0077375
CAS_Registry
  • 22089-22-1
FDA_UNII_Code
  • H64JRU6GJ0
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39725
PDQ_Closed_Trial_Search_ID
  • 39725
Chemical_Formula
  • C9H18Cl3N2O2P
Legacy_Concept_Name
  • Trofosfamide
FULL_SYN
  • TROFOSFAMIDEPTFDAH64JRU6GJ0
  • TrofosfamidSYDTPNSC0109723
  • TrofosfamidSYNCI
  • 2-[bis(2-chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxaphosphorine 2-oxideSNNCI
  • N,N,N'-tris(2-chloroethyl)-N',O-propylene phosphoric acid ester diamideSNNCI
  • TrofosfamideSYDTPNSC0109723
  • TrofosfamidePTNCI
  • A-4828SYDTPNSC0109723
  • Z 4828SYDTPNSC0109723
  • Z-4828SYDTPNSC0109723
  • 2H-1,3,2-Oxazaphosphorin-2-amine, N,N, 3-tris(2-chloroethyl)tetrahydro-, 2-oxide, (+)-SYDTPNSC0314927
  • 2H-1,3,2-Oxazaphosphorin-2-amine, N,N, 3-tris(2-chloroethyl)tetrahydro-, 2-oxide, (-)-SYDTPNSC0314928
  • IxotenSYDTPNSC0109723
  • TrophosphamideSYNCI
  • TrophosphamideSYDTPNSC0109723
  • TrilophosphamideSYNCI
  • A-4828CNNCI
  • Z-4828CNNCI
  • IxotenBRNCI
  • N,N,3-tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxideSNNCI
  • TrilophosphamideSYDTPNSC0109723
  • Genoxal TrofosfamidaFBNCI
DEFINITION
  • An orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), which is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in inhibition of DNA, RNA and protein synthesis, and ultimately lead to tumor cell apoptosis.NCI
code
  • C1268
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