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AttributesValues
rdf:type
rdfs:label
  • Trioxifene
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Trioxifene
UMLS_CUI
  • C0077238
CAS_Registry
  • 63619-84-1
FDA_UNII_Code
  • R0130F043H
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39726
PDQ_Closed_Trial_Search_ID
  • 39726
Chemical_Formula
  • C30H31NO3
Legacy_Concept_Name
  • Trioxifene
FULL_SYN
  • TRIOXIFENEPTFDAR0130F043H
  • (3,4-Dihydro-2-(4-methoxyphenyl)-1-naphthalenyl)(4-(2-(1-pyrrolidinyl)ethoxy)phenyl) MethanoneSNNCI
  • TrioxifenePTNCI
DEFINITION
  • A nonsteroidal selective estrogen receptor modulator (SERM) with potential antineoplastic activity. Trioxifene competes with estradiol in binding to estrogen receptor alpha (ER alpha), thereby inhibiting ER alpha-mediated signal transduction and gene expression. In addition, trioxifene exerts intrinsic estrogenic activity depending on the tissue. Clinical development of trioxifene has not been preceded due to its side effect profile and lack of increased efficacy over tamoxifen.NCI
code
  • C1266
is Has_Free_Acid_Or_Base_Form of
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