About: Trimetrexate Glucuronate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Trimetrexate Glucuronate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Trimetrexate Glucuronate
NSC_Code
  • 352122
UMLS_CUI
  • C0077209
CAS_Registry
  • 82952-64-5
Accepted_Therapeutic_Use_For
  • Head and neck cancer; Metastatic colorectal adenocarcinoma; Non-small cell lung cancer; Osteogenic sarcoma; Pancreatic adenocarcinoma; Pneumocystitis carinii pneumonia
In_Clinical_Trial_For
  • Acute lymphoblastic leukemia; Non-Hodgkins lymphoma; Osteosarcoma
FDA_UNII_Code
  • L137U4A79K
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that belongs to the family of drugs called antimetabolites. It is used in the treatment of pneumocystis carinii pneumonia and is being studied in the treatment of cancer.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39764
PDQ_Closed_Trial_Search_ID
  • 39764
Chemical_Formula
  • C19H23N5O3.C6H10O7
Legacy_Concept_Name
  • Trimetrexate_Glucuronate
FULL_SYN
  • trimetrexate glucuronatePTNCI-GLOSSCDR0000045259
  • Trimetrexate GlucuronatePTNCI
  • TRIMETREXATE GLUCURONATEPTFDAL137U4A79K
  • TRIMETREXATE GLUCURONATESYDTPNSC0352122
  • NeutrexinBRNCI
  • 2,4-Diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline mono-D-glucuronateSNNCI
DEFINITION
  • A lipid soluble methotrexate derivative with potential antineoplastic activity. Trimetrexate glucuronate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate glucuronate also exhibits antiviral activity. (NCI04)NCI
code
  • C1265
is someValuesFrom of
is Has_Salt_Form of
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