About: Trilostane

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Trilostane
rdfs:subClassOf	Steroidal Aromatase Inhibitor 3-Hydroxysteroid Dehydrogenase Inhibitor Anti-Adrenal
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Steroid
Preferred_Name	Trilostane
UMLS_CUI	C0077144
CAS_Registry	13647-35-3
FDA_UNII_Code	L0FPV48Q5R
Contributing_Source	FDA
PDQ_Open_Trial_Search_ID	39812
PDQ_Closed_Trial_Search_ID	39812
Chemical_Formula	C20H27NO3
Legacy_Concept_Name	Trilostane
CHEBI_ID	CHEBI:32260
FULL_SYN	TrilostanePTDCP50561 (4Alpha,5alpha,17beta)-4,5-epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrileSNNCI 2Alpha-cyano-4alpha,5alpha-epoxyandrostan-17beta-ol-3-oneSNNCI DesopanFBNCI TRILOSTANEPTFDAL0FPV48Q5R ModrenalFBNCI WIN 24540CNNCI 4,5-Epoxy-17-hydroxy-3-oxoandrostane-2-carbonitrileSNNCI WIN 24,540CNNCI ModrastaneBRNCI TrilostanePTNCI
DEFINITION	A synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex, resulting in the decreased synthesis of mineralocorticoids and glucocorticoids and the decreased conversion of pregnenolone to progesterone. (NCI04)NCI
DesignNote	This drug has been removed from the US market in 1994.
code	C1263

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