About: Temozolomide

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Attributes	Values
rdf:type	Class
rdfs:label	Temozolomide
rdfs:subClassOf	Triazenes nodeID://b719015 nodeID://b719016 nodeID://b719017
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Temozolomide
NSC_Code	362856
UMLS_CUI	C0076080
CAS_Registry	85622-93-1
Accepted_Therapeutic_Use_For	Malignant glioma (Anaplastic astrocytoma; Anaplastic oligodendrogliomas; Anaplastic oligoastrocytomas; Glioblastoma multiforme); Metastatic melanoma
In_Clinical_Trial_For	Breast cancer; Leukemia Anaplastic astrocytoma; Anaplastic oligodendroglioma; Brain tumors; Cutaneous T-Cell Lymphoma; Glioma; Glioblastoma multiforme; Leiomyosarcoma; Melanoma; Mycosis fungoides; Non-small cell lung cancer; Sezary syndrome; Unspecified solid tumors
FDA_UNII_Code	YF1K15M17Y
Contributing_Source	FDA
ALT_DEFINITION	A drug that is used to treat certain types of brain tumors in adults and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called alkylating agents.NCI-GLOSS
PDQ_Open_Trial_Search_ID	41671
PDQ_Closed_Trial_Search_ID	41671
Chemical_Formula	C6H6N6O2
Legacy_Concept_Name	Temozolomide
FULL_SYN	TEMOZOLOMIDEPTFDAYF1K15M17Y 3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamideSNNCI M and B 39831CNNCI TemozolomideSYDTPNSC0362856 TemozolomidePTNCI MethazolastoneBRNCI temozolomidePTNCI-GLOSSCDR0000045387 MethazolastoneSYDTPNSC0362856 TemozolomidePTDCP50556 Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-SYDTPNSC0362856 imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-SNNCI TemodarPTNCI-GLOSSCDR0000507640 TemodalFBNCI TemodarBRNCI RP-46161CNNCI SCH 52365CNNCI 8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-oneSNNCI CCRG-81045CNNCI M & B 39831CNNCI
DEFINITION	A triazene analog of dacarbazine with antineoplastic activity. As a cytotoxic alkylating agent, temozolomide is converted at physiologic pH to the short-lived active compound, monomethyl triazeno imidazole carboxamide (MTIC). The cytotoxicity of MTIC is due primarily to methylation of DNA at the O6 and N7 positions of guanine, resulting in inhibition of DNA replication. Unlike dacarbazine, which is metabolized to MITC only in the liver, temozolomide is metabolized to MITC at all sites. Temozolomide is administered orally and penetrates well into the central nervous system. (NCI04)NCI
code	C1244
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