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AttributesValues
rdf:type
rdfs:label
  • Sodium Thiosulfate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Inorganic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Sodium Thiosulfate
NSC_Code
  • 45624
UMLS_CUI
  • C0074774
CAS_Registry
  • 10102-17-7
Accepted_Therapeutic_Use_For
  • Cisplatin-induced nephrotoxicity; Nitrogen mustard-induced skin toxicity, neutralizer; Poisoning, arsenic and cyanide
In_Clinical_Trial_For
  • Chemoprotective in glioma and CNS lymphoma
FDA_UNII_Code
  • HX1032V43M
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is used in medicine as an antidote to cyanide poisoning and to decrease side effects of the anticancer drug cisplatin.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39602
PDQ_Closed_Trial_Search_ID
  • 39602
Chemical_Formula
  • 2Na.O3S2.5H2O
Legacy_Concept_Name
  • Sodium_Thiosulfate
CHEBI_ID
  • CHEBI:32150
FULL_SYN
  • Cyanide Antidote PackageBRNCI
  • sodium thiosulfatePTNCI-GLOSSCDR0000350247
  • Disodium thiosulfateSYDTPNSC0045624
  • Sodium ThiosulfatePTDCP01941
  • Thiosulfate, Sodium, PentahydratePTDCP20162
  • S-HydrilSYDTPNSC0045624
  • Sodium ThiosulfatePTNCI
  • Sodium HyposulfateSYNCI
  • SODIUM THIOSULFATEPTFDAHX1032V43M
  • Sodium ThiosulphateSYNCI
  • S-HydrilFBNCI
  • Thiosulfuric acid disodium saltSYDTPNSC0045624
  • Disodium ThiosulfateSYNCI
  • Thiosulfuric Acid Disodium SaltSYNCI
  • SodothiolBRNCI
  • Sodium Thiosulfate PentahydrateSYNCI
  • Sodium thiosulfateSYDTPNSC0045624
DEFINITION
  • A water soluble salt and reducing agent that reacts with oxidizing agents. Although its exact mechanism of action is unknown, thiosulfate likely provides an exogenous source of sulfur, thereby hastening the detoxification of cyanide through the enzyme rhodanese (thiosulfate cyanide sulfurtransferase) which converts cyanide to the relatively nontoxic, excretable thiocyanate ion. In addition, this agent neutralizes the reactive alkylating species of nitrogen mustard, thereby decreasing skin toxicity related to nitrogen mustard extravasation. (NCI04)NCI
code
  • C1230
is someValuesFrom of
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